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Protein and Interactomics

The Laboratory of Protein and Interactomics led by Dr Kong Kin Weng specialises in investigating the bioactivities of edible plants, natural and synthetic compounds. These plants/compounds may have therapeutic implications in chronic diseases such as metabolic-associated fatty liver disease, diabetes and cancers. This lab has established methods for the characterisation of phytochemicals in plant products and employed different biological assays as well as molecular approaches to provide a comprehensive molecular signature of human cells in response to the plant extracts/natural/synthetic compounds.

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Natural products are important sources in discovering therapeutic leads, and this lab mainly studies Malaysian underutilised fruits and vegetables, food processing by-products and medicinal plants. Substantial data has been generated on plant extracts that can prevent oxidative stress, palmitate-induced steatosis, diabetes and glycation. In collaboration with other researchers, small molecules that activate the hypoxic pathway and their effects on lung and liver cancer cell proliferation and migration are also studied. This lab also works on a series of newly synthesised tyrosine kinase inhibitors to identify lead compounds that have therapeutic potential on lung cancer cells by targeting the EGFR pathway. By isolating and characterising beneficial compounds, these compounds may advance into further studies, potentially developing into clinical therapeutics.

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