top of page

Stem Cell Biology

Stem cells are increasingly used to model human disorders, employed as a tool in drug discovery and leveraged for their therapeutic value. In our lab, we have successfully developed stem cell-derived organoids or 3D cultures of the miniature liver, brain, and cartilage along with cancer stem cell models to explore many aspects of biology- molecular and cellular mechanisms, drug testing systems and transplantable cellular resources.

From the perspective of regenerative medicine, we have developed a multiple-cell system using stem cells to study both degenerative diseases and characterise the therapeutic value of stem cells as single and combination therapy as potential treatment modalities for various degenerative conditions. In order to make stem cell transplantation a success, we have been developing rejuvenation strategies for ageing stem cells and expanding their therapeutic value by improving the stem cell bioprocessing pipeline in collaboration with industrial partners. While one arm of the lab is focusing on regenerative medicine, the other arm is dedicated to developing cancer stem cell models and key regulatory targets through integrated multi-omic bioinformatics analysis and targeted regulators that will enable the targeting of the resistant population in a tumour, therefore eradicating cancer. The presentation will highlight on how we can leverage stem cell biology to understand disease mechanisms, modelling the diseases and use them in cell therapy, along with how this may aid to answer some of your research questions and produce a work with high scientific merit.

bottom of page